Role of presynaptic metabotropic glutamate receptors in the induction of long-term synaptic plasticity of vesicular release

Article ID	Journal	Published Year	Pages	File Type
5814994	Neuropharmacology	2013	9 Pages	PDF

Abstract

âº Presynaptic mGluRs are key to short and long-term plasticity of transmitter release. âº mGluRs transiently inhibit vesicular release via release of GÎ²Î³. âº GÎ²Î³ binding the SNAP-25 C-terminus is necessary, not sufficient, for LTD of release. âº GÎ±i2, Nitric oxide, cyclic GMP, cyclic ADP ribose, CaMKinase are all necessary for LTD.

Keywords

SNAP-25 Gαi Group II metabotropic glutamate receptors Vesicular release Gβγ G protein-coupled receptors SNARE protein Synaptic plasticity