| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815008 | Neuropharmacology | 2013 | 9 Pages |
Abstract
⺠mGluR5 activation increases output of pyramidal cells in the medial prefrontal cortex (mPFC). ⺠mGluR5 positive allosteric modulator (PAM) increases excitatory drive onto pyramidal cells. ⺠The direct facilitatory effect of the mGluR5 PAM involves a postsynaptic action on pyramidal cells. ⺠mGluR5 PAM also decreases synaptic inhibition through activation of presynaptic CB1 receptors. ⺠mGluR5 are useful targets to fine-tune mPFC output function.
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Authors
Takaki Kiritoshi, Hao Sun, Wenjie Ren, Shaun R. Stauffer, Craig W. Lindsley, P. Jeffrey Conn, Volker Neugebauer,