A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: Do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression?

► Critically reviews the evidence 'for' and 'against' the monoamine hypothesis. ► Discusses evidence relating to the (neuro)inflammatory theories of depression. ► Evaluates the existing evidence demonstrating the anti-inflammatory effects of SSRIs. ► Examines whether antidepressants improve mood via their anti-inflammatory actions.