Article ID Journal Published Year Pages File Type
5815090 Neuropharmacology 2013 8 Pages PDF
Abstract
► NMDA receptor-mediated nitric oxide production depends on NMDA/PSD-95/nNOS coupling. ► NMDAR antagonism (MK-801) and PSD-95 inhibition (UCCB01-125) reduced inflammatory pain. ► The analgesic dose of MK-801 was associated with cognitive and motor side effects. ► Supra-analgesic doses of UCCB01-125 were devoid of cognitive and motor side-effects.
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Life Sciences Neuroscience Behavioral Neuroscience
Preview
UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801
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