| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815116 | Neuropharmacology | 2013 | 10 Pages |
Abstract
⺠BMS-763534, a potent and selective novel CRF1 receptor antagonist, is characterized. ⺠BMS-763534 acted as a negative allosteric modulator of CRF binding. ⺠BMS-763534 was anxiolytic at doses producing â¥70% CRF1 receptor occupancy in the brain. ⺠A BMS-763534 metabolite was a low potency potentiator of GABA currents.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Nicholas J. Lodge, Snjezana Lelas, Yu-Wen Li, Thaddeus Molski, James Grace, Digavalli V. Sivarao, Debra Post-Munson, Francine Healy, Joanne J. Bronson, Richard Hartz, John E. Macor, Robert Zaczek,