| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815167 | Neuropharmacology | 2013 | 11 Pages |
Abstract
⺠We studied stereo-specific anti-ischemic effects of trans- and cis-hinokiresinols. ⺠The two isomers similarly scavenged free radicals. ⺠Only trans-isomer up-regulated Cu/Zn-SOD and showed anti-ischemic activity in vitro. ⺠In a rat model, the two isomers reduced cerebral infarct in stereo-specific manners. ⺠Different anti-oxidant/anti-inflammatory activities explain the stereo-specificity.
Keywords
NMDA1, 1-diphenyl-2-picrylhydrazylDHR123DCF-DAMCAON-methyl-d-aspartateRNSAAPHDPPHORACMPODHETOGD/RROSSIN-1, 3-morpholinosydnonimineAntioxidantmiddle cerebral artery occlusiondihydrorhodamine 123Dihydroethidinedichlorofluorescein diacetateSODSuperoxide dismutaseAnti-inflammationoxygen radical absorbance capacitylactate dehydrogenaseLDHOxygen-glucose deprivationmyeloperoxidasePropidium iodideTherapeutic windowreactive nitrogen speciesReactive oxygen species
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Authors
Chung Ju, Sunyoung Hwang, Geum-Sil Cho, Gajulapati Kondaji, Sumi Song, Paul L. Prather, Yongseok Choi, Won-Ki Kim,