| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815176 | Neuropharmacology | 2013 | 9 Pages |
Abstract
⺠Neonatal presynaptic LTP (npLTP) manifests as a strong decrease in synaptic facilitation. ⺠npLTP is induced by physiologically relevant Hebbian protocols at immature synapses. ⺠The induction involves postsynaptic calcium, NMDA-receptors and PKA. ⺠PKC is selectively needed for npLTP but not for other forms of synaptic potentiation. ⺠This mechanism may drive activity-dependent maturation of presynaptic function.
Keywords
TrkB1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)QX-314presynapticMK801PKCAP5pKa2-amino-5-phosphonopentanoic acidBDNFRelease probabilitylong-term depressioncornu ammonisBISlong-term potentiationLTPDevelopmentpostnatal daybrain derived neurotrophic factorLTDtropomyosin-related kinase Bprotein kinase AProtein kinase C
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Authors
Natalia V. Luchkina, Marko Sallert, Vernon R.J. Clarke, Tomi Taira, Sari E. Lauri,