| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815298 | Neuropharmacology | 2012 | 15 Pages |
Abstract
⺠Glutamatergic receptors in the prefrontal neurons in MK-801 model were investigated. ⺠MK-801 induced distinct changes in AMPA and NMDAR receptors in FS interneurons. ⺠New presynaptic NMDARs were inserted in terminals targeting pyramidal neurons. ⺠These data provide a mechanistic explanation for the NMDA hypofunction hypothesis.
Keywords
PFCcalcium-permeable AMPA receptorsCP-AMPARsrectification indexNMDAMK-801NMDA receptor hypofunctionEPSCsN-methyl-d-aspartic acidDNQX6,7-dinitroquinoxaline-2,3-dioneD-(−)-2-amino-5-phosphonopentanoic acidd-AP5Schizophreniaγ-aminobutyric acidfast-spiking interneuronsexcitatory postsynaptic currentsfast-spikingprefrontal cortexGABAAMPA receptors
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Authors
Huai-Xing Wang, Wen-Jun Gao,