| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815319 | Neuropharmacology | 2012 | 8 Pages |
Abstract
⺠Ketogenic diet (KD) is highly effective in drug-resistant epilepsy. ⺠Its mechanism of action is unknown. ⺠Caprylic acid (CA) is the main constituent of the medium-chain triglyceride (MCT) KD. ⺠Here, CA showed acute anticonvulsant properties alone and in combination with valproate in mice. ⺠We propose, anticonvulsant properties of CA may add to the overall clinical efficacy of the MCT KD.
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Authors
Piotr Wlaź, Katarzyna SocaÅa, Dorota Nieoczym, Jarogniew J. Åuszczki, Iwona Å»arnowska, Tomasz Å»arnowski, StanisÅaw J. Czuczwar, Maciej Gasior,