| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815332 | Neuropharmacology | 2013 | 14 Pages |
Abstract
⺠Cognitive decline is a major problem facing an ageing human population. ⺠NMDA receptors play an important role in neural plasticity and learning and memory. ⺠Excessive activation of NMDA receptors results in deleterious effects. ⺠Subtle fine-tuning of NMDAR function is needed for control of cognitive decline. ⺠Positive allosteric modulators of NMDARs can affect NMDAR mediated events.
Keywords
GPCRPKCfEPSPNMDARD1RmGluRIPSPPSD95AChRCK2PAC1RpKaCaMKIIAMPARA-kinase anchoring proteinsmAChRdopamine 1 receptorEPSCEPSPG-protein-coupled receptorsiGluRNMDA receptorCognitive enhancementsynaptic transmissionlong-term potentiationLTPexcitatory postsynaptic currentPositive allosteric modulatorsHippocampusexcitatory postsynaptic potentialinhibitory postsynaptic potentialfield excitatory postsynaptic potentialspostsynaptic density protein 95protein kinase AProtein kinase CCa2+/calmodulin-dependent protein kinaseSynaptic plasticitycasein kinase IIGABAARGABABRSTEPAMPA receptorGABAA receptorGABAB receptoracetylcholine receptormuscarinic acetylcholine receptorMetabotropic glutamate receptorionotropic glutamate receptor
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Authors
Graham L. Collingridge, Arturas Volianskis, Neil Bannister, Grace France, Lydia Hanna, Marion Mercier, Patrick Tidball, Guangyu Fang, Mark W. Irvine, Blaise M. Costa, Daniel T. Monaghan, Zuner A. Bortolotto, Elek Molnár, David Lodge, David E. Jane,