Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5815334 | Neuropharmacology | 2013 | 8 Pages |
Abstract
⺠ZIP is a competitive PKMζ inhibitor that blocks PKMζ-mediated synaptic potentiation. ⺠Chelerythrine is a redox-sensitive PKC inhibitor, effective on PKMζ. ⺠High levels of PKMζ render standard doses of ZIP and chelerythrine ineffective. ⺠Overexpression methodologies increase PKMζ 30- to 40-fold over endogenous levels. ⺠Staurosporine does not inhibit PDK1 phosphorylation of endogenous PKMζ in neurons.
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Authors
Yudong Yao, Charles Shao, Desingarao Jothianandan, Andrew Tcherepanov, Harel Shouval, Todd Charlton Sacktor,