Article ID Journal Published Year Pages File Type
5815334 Neuropharmacology 2013 8 Pages PDF
Abstract
► ZIP is a competitive PKMζ inhibitor that blocks PKMζ-mediated synaptic potentiation. ► Chelerythrine is a redox-sensitive PKC inhibitor, effective on PKMζ. ► High levels of PKMζ render standard doses of ZIP and chelerythrine ineffective. ► Overexpression methodologies increase PKMζ 30- to 40-fold over endogenous levels. ► Staurosporine does not inhibit PDK1 phosphorylation of endogenous PKMζ in neurons.
Related Topics
Life Sciences Neuroscience Behavioral Neuroscience
Authors
, , , , , ,