| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815341 | Neuropharmacology | 2013 | 16 Pages |
Abstract
⺠Identified “crebinostat”, a novel HDAC inhibitor, in a CREB reporter gene screen. ⺠Crebinostat inhibits HDACs 1-3 and 6; and induces histone acetylation. ⺠Crebinostat regulates neuronal genes involved in synaptic function and cognition. ⺠Crebinostat enhances performance in fear conditioning learning in mice.
Keywords
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Daniel M. Fass, Surya A. Reis, Balaram Ghosh, Krista M. Hennig, Nadine F. Joseph, Wen-Ning Zhao, Thomas J.F. Nieland, Ji-Song Guan, Chelsea E. Groves Kuhnle, Weiping Tang, Douglas D. Barker, Ralph Mazitschek, Stuart L. Schreiber, Li-Huei Tsai,