| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815346 | Neuropharmacology | 2013 | 10 Pages |
Abstract
⺠We report that tadalafil crosses the blood-brain barrier. ⺠The amount fo tadalafil that reached the brain at the dose administered, is enough to inhibit PDE5. ⺠The administration of PDE5 inhibitors reverses memory deficits in an AD mice model. ⺠PDE5 inhibitors induced a decrease in Tau pathology but no effect was observed in amyloid burden.
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Authors
Carolina GarcÃa-Barroso, Ana Ricobaraza, MarÃa Pascual-Lucas, Nora Unceta, Alberto J. Rico, Maria Aranzazu Goicolea, Joan Sallés, José Luis Lanciego, Julen Oyarzabal, Rafael Franco, Mar Cuadrado-Tejedor, Ana GarcÃa-Osta,