| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815348 | Neuropharmacology | 2013 | 8 Pages |
Abstract
⺠Propranolol attenuated cognitive memory impairments in SAMP8 mice in NORT. ⺠SAMP8 show increases in Aβ42 levels and BACE1 expression and decreased IDE expression. ⺠Increases in pTau related to a decrease in JNK1 expression were shown by SAMP8 mice. ⺠SAMP8 mice displayed synaptic pathology, as shown by decreases in synaptophysin and BDNF. ⺠Amyloid, Tau and synaptic pathology in SAMP8 mice all reversed by propranolol.
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Authors
Marta Dobarro, Lourdes Orejana, Norberto Aguirre, MarÃa Javier RamÃrez,