| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815372 | Neuropharmacology | 2013 | 16 Pages |
Abstract
⺠Two novel mGlu5 potentiators are described, LSN2463359 and LSN2814617. ⺠Both compounds show high in vitro potency and low curve shift ratios. ⺠Brain penetrance and MPEPy displacement in vivo was dose-dependent. ⺠Both compounds markedly increased wakefulness without disrupting operant behaviour. ⺠Both compounds attenuated NMDA antagonist impairments of operant behaviour.
Keywords
NMDADelayed-matching-to-positionRFUADX47273mGluCDPPBCHPGN-methyl-d-aspartateLMAPAMANCOVADMTPNMDA receptor antagonistSchizophreniaElectroencephalogramEMGelectromyogramanalysis of covarianceanalysis of varianceANOVACircadian TimePsychosisVariable intervalLocomotor activitypositive allosteric modulatorEEGglutamatemGlu5 receptorMetabotropic glutamate receptor
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Authors
Gary Gilmour, Lisa M. Broad, Keith A. Wafford, Thomas Britton, Ellen M. Colvin, Adam Fivush, Francois Gastambide, Brian Getman, Beverly A. Heinz, Andrew P. McCarthy, Lourdes Prieto, Elaine Shanks, Janice W. Smith, Lorena Taboada, Dale M. Edgar,