| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815488 | Neuropharmacology | 2012 | 14 Pages |
Abstract
⺠Neurons are generated throughout life from stem/progenitor cells in the hippocampus. ⺠New neurons are suggested to be important for depression pathophysiology/treatment. ⺠Ablation of neurogenesis is not usually sufficient to induce depression or anxiety. ⺠Antidepressant-induced neurogenesis is context- and strain-dependent. ⺠Neurogenesis is required for behavioral responses in specific models of depression.
Keywords
GFAPMDDMAMUCMSCRF1SGZCMSpost-traumatic stress disorderPTSDMajor depressive disorderSocial defeat stresschronic mild stressUnpredictable chronic mild stressAnxietyDepressionBrdUbromodeoxyuridinethymidine kinasedentate gyrusmethylazoxymethanol acetatesubgranular zoneSelective serotonin reuptake inhibitorSSRIadult neurogenesisHippocampusGlial fibrillary acidic proteinCORTCorticosterone
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Authors
David Petrik, Diane C. Lagace, Amelia J. Eisch,