| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815489 | Neuropharmacology | 2012 | 7 Pages |
Abstract
⺠Clinical studies demonstrate that ketamine produces a rapid antidepressant response. ⺠Ketamine rapidly increases synaptogenesis in rodent prefrontal cortex. ⺠Ketamine-induction of synaptogenesis requires mTOR signaling. ⺠Ketamine rapidly reverses synaptic loss caused by stress and depression. ⺠Ketamine results in a functional reconnection of neurons.
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Authors
Ronald S. Duman, Nanxin Li, Rong-Jian Liu, Vanja Duric, George Aghajanian,