Article ID Journal Published Year Pages File Type
5815507 Neuropharmacology 2012 6 Pages PDF
Abstract
► Hippocampal theta rhythms are associated with anxiety and suppressed by known anxiolytic drugs. ► Theta suppression has been used as a neurophysiological model for anxiolysis. ► Prior validation of this model has used known anxiolytics, thus, a critical test would use a non- or unknown anxiolytic. ► INaP currents are necessary for the expression of hippocampal theta, and are suppressed by the anticonvulsant phenytoin. ► Phenytoin suppressed both theta and anxious behaviour in the plus-maze, providing prima facie validation for the model.
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