Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5815507 | Neuropharmacology | 2012 | 6 Pages |
Abstract
⺠Hippocampal theta rhythms are associated with anxiety and suppressed by known anxiolytic drugs. ⺠Theta suppression has been used as a neurophysiological model for anxiolysis. ⺠Prior validation of this model has used known anxiolytics, thus, a critical test would use a non- or unknown anxiolytic. ⺠INaP currents are necessary for the expression of hippocampal theta, and are suppressed by the anticonvulsant phenytoin. ⺠Phenytoin suppressed both theta and anxious behaviour in the plus-maze, providing prima facie validation for the model.
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Authors
Michelle Yeung, Dallas Treit, Clayton T. Dickson,