| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815601 | Neuropharmacology | 2012 | 11 Pages |
Abstract
⺠The 3β-HSD inhibitor trilostane increased plasma PROG and brain PREG. ⺠In the FST, trilostane facilitated DHEAS activity and SSRI effects at high doses. ⺠Trilostane moderately increased brain monoamine turnover. ⺠Trilostane's antidepressant potential is due to subtle changes in steroid levels. ⺠Trilostane may be useful as co-treatment with SSRI.
Keywords
5-HIAADHEAACTHTrilostaneMHPG3β-Hydroxysteroid dehydrogenaseDeoxycorticosteronePROGs.c.THDOCDHEAS3α-HSOR5-HTDOPACEPIDOCdehydroepiandrosteronei.p.3,4-dihydroxyphenylacetic acid5-hydroxyindole-3-acetic acidBDNFneurosteroidsadrenocorticotropinForced swimming testPREGSDepressionALLOpregnenoloneIntraperitoneallyDopaminesubcutaneouslySerotoninBrain-derived neurotrophic factorCSFCerebrospinal fluidSelective serotonin reuptake inhibitorSSRIMonoamineshomovanillic acidProgesteronePREGHVA
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Authors
Julie Espallergues, Takayoshi Mamiya, Monique Vallée, Takenao Koseki, Toshitaka Nabeshima, Jamal Temsamani, Claude Laruelle, Tangui Maurice,