| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815612 | Neuropharmacology | 2012 | 7 Pages |
Abstract
⺠We studied the therapeutic effect of memantine in a mouse model of Batten disease. ⺠Acute treatment had no effect on the impaired motor skills of 1-month-old mice. ⺠Acute treatment induced a prolonged improvement in 6-7-month-old Cln3Îex1-6 mice. ⺠Acute treatment in 6-7-month-old Cln3Îex1-6 mice did not affect neuropathology. ⺠Repeated treatment in 6-month-old Cln3Îex1-6 mice did not improve the motor skills.
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Authors
Attila D. Kovács, Angelika Saje, Andrew Wong, Serena Ramji, Jonathan D. Cooper, David A. Pearce,