Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex

Article ID	Journal	Published Year	Pages	File Type
5815616	Neuropharmacology	2012	12 Pages	PDF

Abstract

âº The onset of spontaneous seizures was highly variable (3-36 days) with an average latency of 15 days. âº Massive neurodegeneration was already present 24Â h after KA-induced seizures. âº Neurons of the proximal subiculum and EC layer III preferentially degenerate. âº Distribution of reactive gliosis roughly matches the pattern of neurodegeneration. âº Time course of reactive gliosis parallels that of epileptogenesis.

Keywords

GFAP NeuN TLE VGLUT1 kainic acid epileptogenesis status epilepticus vesicular glutamate transporter 1 SUB Subiculum dentate gyrus temporal lobe epilepsy Entorhinal cortex EEG Glial fibrillary acidic protein neuron-specific nuclear protein