| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815645 | Neuropharmacology | 2012 | 9 Pages |
Abstract
⺠Ifenprodil alone or together with PEAQX inhibits glutamate-induced Ca dysregulation. ⺠Ifenprodil is more effective in younger (6-8 DIV) than in older (13-16 DIV) neurons. ⺠Ifenprodil but not AP-5 or PEAQX inhibits reverse Na/Ca exchanger (NCXrev). ⺠Ifenprodil-like NMDAR antagonists Ro 25-6981 and Co 101244 also inhibit NCXrev. ⺠Both NMDAR and NCXrev are essential for the glutamate-induced Ca2+ dysregulation.
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Authors
Matthew K. Brittain, Tatiana Brustovetsky, Joel M. Brittain, Rajesh Khanna, Theodore R. Cummins, Nickolay Brustovetsky,