Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5815653 | Neuropharmacology | 2012 | 10 Pages |
Abstract
⺠Depressed patients exhibit deficits in probabilistic reversal learning (PRL). ⺠A PRL paradigm was developed for C57BL/6 mice. ⺠Operant responding was sensitive to probability of punished correct responses (PCR). ⺠Heterozygous serotonin transporter mutant mice exhibited reduced sensitivity to PCR. ⺠Low-acute SSRI escitalopram administration also reduced sensitivity to PCR.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Christian Ineichen, Hannes Sigrist, Simona Spinelli, Klaus-Peter Lesch, Eva Sautter, Erich Seifritz, Christopher R. Pryce,