| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815669 | Neuropharmacology | 2012 | 8 Pages |
Nerve growth factor (NGF) is a critical secreted protein that plays an important role in development, survival, and function of the mammalian nervous system. Previously reports suggest that endogenous NGF is essential for the hippocampal plasticity/memory and NGF deprivation induces the impairment of hippocampus-related memory and synaptic plasticity. However, whether exogenous supplement of NGF could promote the hippocampus-dependent synaptic plasticity/memory and the possible underlying mechanisms are not clear. In this study we found that NGF administration facilitates the hippocampus-dependent long-term memory and synaptic plasticity by increasing the activity of PARP-1, a polymerase mediating the PolyADP-ribosylation and important for the memory formation. Co-application of 3-Aminobenzamide (3-AB), a specific inhibitor of PARP-1, distinctly blocked the boosting effect of NGF on memory and synaptic plasticity, and the activation of downstream PKA-CREB signal pathway. Our data provide the first evidence that NGF supplement facilitates synaptic plasticity and the memory ability through PARP-1-mediated protein polyADP-ribosylation and activation of PKA-CREB pathway.
⺠NGF promotes the hippocampus-dependent long term memory and synaptic plasticity. ⺠NGF doesn't affect amygdale-dependent long term memory. ⺠NGF activates PARP-1 to mediate PolyADP-ribosylation. ⺠PARP-1 activates cAMP-PKA-CREB signal pathway.
