| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815701 | Neuropharmacology | 2011 | 10 Pages |
Abstract
⺠In this study, we developed and synthesized a series of endomorphin degradation blockers. ⺠We demonstrated that the novel inhibitors of EM-degrading enzymes prolong EM analgesic and antidepressant-like effects. ⺠These inhibitors might become potential candidates for lead compounds in a new therapeutic strategy against pain and mood disorders.
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Authors
Aurore Cravezic, Jakub Fichna, Katarzyna Gach, Anna Wyrebska, Renata Perlikowska, Jean Costentin, Jean-Jacques Bonnet, Anna Janecka, Jean-Claude do Rego,