Article ID Journal Published Year Pages File Type
5815704 Neuropharmacology 2011 9 Pages PDF
Abstract
► We investigated the synaptic mechanism of carisbamate in the dentate gyrus. ► Carisbamate inhibited glutamatergic transmission. ► GABAergic transmission and neuronal excitability were not affected. ► The antiepileptic effect of carisbamate is from inhibiting presynaptic Na channels.
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Life Sciences Neuroscience Behavioral Neuroscience
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Carisbamate (RWJ-333369) inhibits glutamate transmission in the granule cell of the dentate gyrus
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