Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5815708 | Neuropharmacology | 2011 | 10 Pages |
Abstract
⺠Effects of IGF-1 on expression and function of NaV1.7 Na+ channels are investigated. ⺠IGF-1 up-regulates NaV1.7 Na+ channels via acceleration of α-subunit gene transcription. ⺠PI3Kâ¼Aktâ¼GSK-3β pathway is involvement in the increasing effect of IGF-1. ⺠IGF-1 enhances Na+ influx, and subsequent Ca2+ influx and catecholamine secretion.
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Authors
Toshihiko Yanagita, Shinya Satoh, Yasuhito Uezono, Kiyotaka Matsuo, Takayuki Nemoto, Toyoaki Maruta, Norie Yoshikawa, Tomomi Iwakiri, Kouichiro Minami, Manabu Murakami,