Intact attentional processing but abnormal responding in M1 muscarinic receptor-deficient mice using an automated touchscreen method

► We examined the functional role of the M1 receptor in cognition. ► We report abnormal responding of M1 knockout mice in the touchscreen 5-CSRTT. ► M1R−/− mice were unimpaired in touchscreen learning, memory, and perception tasks. ► M1R−/− mice were impaired at object recognition memory with a delay. ► M1R is involved in distinct aspects of cognition.