Ethanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage

► Synapse damage in neurons was induced by amyloid-β (Aβ)1-42 and natural Aβ oligomers. ► Ethanol protects neurons against Aβ-induced synapse damage. ► Ethanol protects neurons against synapse damage induced by α-synuclein. ► Ethanol reduces Aβ and αSN-induced activation of cytoplasmic phospholipase A2.