| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815765 | Neuropharmacology | 2012 | 9 Pages |
Abstract
⺠A concatamer of human α3 and β4 nAChR subunits was constructed for expression in Xenopus oocytes. ⺠Insertion of specific subunits was confirmed with selective antagonists and resistant mutants. ⺠No effects of the α5 D376N SNP were observed on agonist-evoked responses of α3β4α5 receptors. ⺠Compared to rat, human α3β4 receptors respond more to varenicline and less to cytisine. ⺠Our data will potentially impact the side-effect liability of agents used for smoking cessation.
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Authors
Clare Stokes, Roger L. Papke,