Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5815774 | Neuropharmacology | 2012 | 7 Pages |
Abstract
⺠Calpain inhibitor A-705253 examined in acute models of tau hyperphosphorylation. ⺠A-705253 blocked in vitro low temperature-induced tau phosphorylation in hippocampal slices. ⺠A-705253 blocked in vivo stress-induced tau hyperphosphorylation in mice. ⺠A-705253 decreased expression of the calpain proteolytic p25 fragment.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Arthur L. Nikkel, Brenda Martino, Stella Markosyan, Jill-Desiree Brederson, Rodrigo Medeiros, Achim Moeller, Robert S. Bitner,