| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815786 | Neuropharmacology | 2012 | 8 Pages |
Abstract
⺠Mgl-2, a Caenorhabditis elegans receptor had lower affinity for glutamate compared to rat mGluR5. ⺠Negative allosteric modulators were ineffective at mgl-2. ⺠CDPPB, an mGluR5 positive allosteric modulator, potentiated glutamate. ⺠The glutamate site is conserved whereas allosteric sites show evolutionary changes.
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Authors
Sujeenthar Tharmalingam, Andrew R. Burns, Peter J. Roy, David R. Hampson,