Ginsenoside Rg1 protection against Î²-amyloid peptide-induced neuronal apoptosis via estrogen receptor Î± and glucocorticoid receptor-dependent anti-protein nitration pathway

Article ID	Journal	Published Year	Pages	File Type
5815804	Neuropharmacology	2012	13 Pages	PDF

Abstract

âº AÎ²-induced neuronal apoptosis is via selective protein tyrosine nitration pathway. âº Activation of both ERÎ± and GR contribute to the neuroprotective effects of Rg1. âº Rg1 ameliorates AÎ²-induced neuronal insults by two complementary pathways. âº Maintaining ERK1/2 phosphorylation is important for Rg1 neuroprotection. âº Inhibiting of NF-ÎºB activation contributes to the protective effects of Rg1.

Keywords

Ginsenoside Rg1 U0126 NF-κB ERK1/2 phosphorylation RU486 DEX DAPI Rg1 RMSD iNOS PROG GAPDH 17β-estradiol Aβ25–35 MTT Small interfering RNA ROS siRNA β-Amyloid ACh Acridine orange ethidium bromide Acetylcholine root-mean-square deviation Alzheimer’s disease Dexamethasone inducible nitric oxide synthase nuclear factor κB Protein tyrosine nitration Nitric oxide Progesterone Molecular dynamic ChAT choline acetyltransferase glyceraldehyde-3-phosphate dehydrogenase Reactive oxygen species Estrogen receptor Progesterone receptor glucocorticoid receptor