| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815805 | Neuropharmacology | 2012 | 6 Pages |
Abstract
⺠The 5-HT1 receptor agonist sumatriptan is an effective migraine therapeutic. ⺠The antimigraine anatomical locus and mechanisms of action remain unresolved. ⺠We show sumatriptan acts peripherally at individual dural CGRP pain fibre terminals. ⺠N-type Ca2+ channels selectively mediate sumatriptan inhibition of Ca2+ signaling. ⺠Findings provide insight for developing novel peripherally targeted therapeutics.
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Authors
Landon D. Baillie, Andrew H. Ahn, Sean J. Mulligan,