Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5815852 | Neuropharmacology | 2012 | 9 Pages |
Abstract
⺠Wild-type and dopamine transporter (DAT) knockout mice are studied using dual (15-s and 45-s) and single (20-s) peak-interval timing procedures. ⺠We examine changes in interval timing as a function of DAT gene deletions. ⺠DAT â/â mice were unable to exhibit temporal control of lever pressing, while DAT +/â mice were able to time in a manner similar to DAT +/+ mice unless challenged with methamphetamine injections. ⺠Observations are discussed in terms of hyperdopaminergic effects in cortical-striatal circuits.
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Authors
Warren H. Meck, Ruey-Kuang Cheng, Christopher J. MacDonald, Raul R. Gainetdinov, Marc G. Caron, Münire Ãzlem Ãevik,