Article ID Journal Published Year Pages File Type
5815852 Neuropharmacology 2012 9 Pages PDF
Abstract
► Wild-type and dopamine transporter (DAT) knockout mice are studied using dual (15-s and 45-s) and single (20-s) peak-interval timing procedures. ► We examine changes in interval timing as a function of DAT gene deletions. ► DAT −/− mice were unable to exhibit temporal control of lever pressing, while DAT +/− mice were able to time in a manner similar to DAT +/+ mice unless challenged with methamphetamine injections. ► Observations are discussed in terms of hyperdopaminergic effects in cortical-striatal circuits.
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