DISC1-binding proteins in neural development, signalling and schizophrenia

Article ID	Journal	Published Year	Pages	File Type
5815854	Neuropharmacology	2012	12 Pages	PDF

Abstract

âº We review genetic data associating DISC1 with psychiatric illness. âºÂ DISC1 binding partners include proteins involved in neuronal migration. âºÂ Others are involved in neuronal signalling or synaptic function. âºÂ These binding partners suggest putative disease-related molecular pathways. âºÂ Several are now also implicated in psychiatric illness in their own right.

Keywords

GluR NRG LEF/TCF LIS1 PDE4 Pericentrin DBZ DIXDC1 FEZ1 CNV GSK3β Pcm1 CEP290 PACAP Rac1 PCNT CRE ATF4 PSD BACE1 mTOR APP PI3 K Ndel1 DISC1 Disrupted in Schizophrenia 1 Schizophrenia Post-synaptic density copy number variation neurodevelopment TNIK Ras-related C3 botulinum toxin substrate 1 Signalling cAMP response element phosphodiesterase 4 activating transcription factor 4 Association studies Nde1 Neuregulin mammalian target of rapamycin Synapse amyloid precursor protein pituitary adenylate cyclase-activating polypeptide Glycogen synthase kinase 3β Glutamate receptor