| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815912 | Neuropharmacology | 2012 | 20 Pages |
Abstract
⺠This review describes the role of the d-serine pathway in schizophrenia pathogenesis. ⺠Genetic studies associate genes regulating d-serine availability with increased schizophrenia risk. ⺠Postmortem schizophrenia studies observe abnormalities in d-serine modulatory enzymes. ⺠In vivo findings report altered levels of endogenous NMDA receptor co-agonist site ligands in schizophrenia. ⺠Genetic animal models with aberrant NMDA receptor co-agonist site function display schizophrenia-like symptoms.
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Authors
Viviane Labrie, Albert H.C. Wong, John C. Roder,