Influence of social isolation in the rat on serotonergic function and memory - Relevance to models of schizophrenia and the role Â of 5-HT6 receptors

Article ID	Journal	Published Year	Pages	File Type
5815950	Neuropharmacology	2011	8 Pages	PDF

Abstract

âº The isolation reared rat is a preclinical neurodevelopmental model of schizophrenia. âº Isolation causes aberrant hippocampal neuronal plasticity impairing cognition. âº This review examines neural changes accompanying novel object discrimination deficits. âº 5-HT6 antagonists reverse discrimination impairments in isolation reared rats. âº Altered GABA and glutamate function by 5-HT6 antagonists may account for this effect.

Keywords

PFC PPI 5-hydroxytryptamine MPEP Prepulse inhibition of acoustic startle 2-methyl-6-(phenylethynyl)-pyridine Schizophrenia Cer Serotonin Cognition prefrontal cortex Conditioned emotional response Isolation rearing glutamate Learning and memory