| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5815965 | Neuropharmacology | 2011 | 6 Pages |
Abstract
⺠5-HT2cR agonist suppresses limbic theta rhythm in waking and REM sleep (by 20%, 57%). ⺠mCPP also suppressed brainstem stimulation-elicited theta rhythm under anesthesia (62%). ⺠The effect was dose-dependent and was antagonized with 5-HT2cR antagonist, SB-242084. ⺠Thus, serotonin modulation of theta activity involves 5-ht2c receptor mechanism. ⺠Drugs acting on 5-HT2cR may affect theta-associated pathological processes of cognition.
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Authors
Elin Sörman, Dannie Wang, Mihaly Hajos, Bernat Kocsis,