| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5816022 | Neuropharmacology | 2011 | 8 Pages |
Abstract
⺠The [3H]LY341495 binding was significantly increased by rearing in social isolation. ⺠The effect was specific for the prefrontal cortex and hippocampus. ⺠The Bmax value increased significantly without any changes in the Kd value. ⺠The mGluR2/3 antagonist showed an antidepressant effect in isolation-reared mice. ⺠The increased receptor function may contribute to the pathogenic mechanisms.
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Authors
Toshiyuki Kawasaki, Yukio Ago, Koji Yano, Ryota Araki, Yusuke Washida, Hirotaka Onoe, Shigeyuki Chaki, Atsuro Nakazato, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda,