Effects of cannabinoid CB1 receptor agonism and antagonism on SKF81297-induced dyskinesia and haloperidol-induced dystonia in Cebus apella monkeys

► In Cebus monkeys, D1 agonist-induced oral dyskinesia was reduced by CB1 agonism. ► D1 agonist-induced oral dyskinesia was not reduced by CB1 antagonism. ► D2 antagonist-induced dystonia was not affected by CB1 agonism or antagonism. ► CB1 agonism may reduce dyskinesia associated with chronic antipsychotic treatment.