Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor

Article ID	Journal	Published Year	Pages	File Type
5816053	Neuropharmacology	2011	9 Pages	PDF

Abstract

âº BZD modulators induce structural rearrangements at the GABA binding interface. âº Pentobarbital and BZDs induce different movements at the GABA binding interface. âº BZD-induced movements are likely correlated with the efficacy of BZD modulation.

Keywords

BZD MTSES Ro15-1788 DMCM AChBP GLIC ELIC LGIC benzodiazepine oocyte expression Flumazenil Allosteric modulation acetylcholine binding protein Pentobarbital ligand-gated ion channel GABA GABAR GABA-A receptor GABAA receptor