Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5816515 | Phytomedicine | 2014 | 10 Pages |
Abstract
Different manufacturing processes lead to different herbal preparations. A systems biology approach combining a metabolomic plant analysis with a functional characterization by gene expression profiling in HepG2 cells is an appropriate strategy to characterize variations in plant extracts. Safety assessments of herbal substances may benefit from such complementary analyses.
Keywords
CYP3A4CYP2B6GSTO2CYP19A1IGFBP1GSTP1CYP3A7AKR1B10CYP4V2CYP1B1CYP24A1HMOX1CYP8B1Egr2IPACYP1A1cyp26a1qRT-PCRGlutathione S-transferase PBile acid-CoA:amino acid N-acyltransferaseAHRRBAATPCAIngenuity Pathway AnalysisPrincipal component analysisgene expression profilingheme oxygenase (decycling) 1quantitative real-time PCRInsulin-like growth factor-binding protein 1
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Authors
A. Orland, K. Knapp, G.M. König, G. Ulrich-Merzenich, W. KnöÃ,