Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5816589 | Phytomedicine | 2014 | 8 Pages |
Abstract
The purpose of this study was to investigate the underlying mechanism(s) of the total alkaloids (TA) from Mahonia bealei in treating pyloric ligation-induced gastric ulcers in rats. Animals were sacrificed after 19Â h of the ligation. Gastric acid, peptic activities, mucin levels, H+/K+-ATPase activities and the gastrin level were analyzed. To improve the accuracy of the observations, IPP 6.0 software was introduced to measure the area of ulcer. TA (18.56Â mg/kg/day, i.g.) showed an antiulcer effect by significantly decreasing the gastric ulcer areas (11.28Â mm2) compared with model group (26.36Â mm2). The TA ulcer inhibition ratio was 57.2%, compared with the effect of the positive control, omeprazole (62.96%). The results also showed that TA had a significant effect in inhibiting the release of H+/K+-ATPase, reducing the content of gastrin and decreasing gastric acidity on experimental animals. However, the TA had no significant effects on gastric mucus secretion and pepsin activity. Data indicated that TA had gastric ulcer protective effects by modulating the H+/K+-ATPase activity and gastrin level. TA has a potential to be developed as a pharmacological agent for the treatment of gastric ulcers.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Clinical Biochemistry
Authors
Su-Li Zhang, Hui Li, Xin He, Run-Qi Zhang, Yu-He Sun, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan,