Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5816666 | Phytomedicine | 2013 | 5 Pages |
Abstract
In continuation of our drug discovery programme on Indian medicinal plants, we isolated an unusual amino acid, i.e. 2-amino-5-hydroxyhexanoic acid (1) from the seeds of Crotalaria juncea. The 2-amino-5-hydroxyhexanoic acid (1) showed dose dependent lipid lowering activity in the in vivo experiments and also showed good in vitro antioxidant activity. The cyclized compound, 3-amino-6-methyltetrahydro-2H-pyran-2-one (2) showed better lipid lowering and antioxidant profile than the parent compound 1.
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Authors
Janki Prasad, Vinay Kr. Singh, Atul Shrivastava, Upma Chaturvedi, Gitika Bhatia, K.R. Arya, S.K. Awasthi, T. Narender,