Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5816813 | Phytomedicine | 2012 | 5 Pages |
Abstract
Changes induced by MEO (25, 50 and 100Â mg/kg) and reference drug caffeine (25Â mg/kg) in spontaneous locomotor activities and motor coordinations of mice were investigated by activity cage measurements and Rota-Rod tests, respectively. Open field, social interaction and elevated plus-maze tests were applied to assess the emotional state of the animals. Further, tail-suspension test was performed for evaluating the effect of MEO on depression levels of mice. As a result, at 50 and 100Â mg/kg, MEO significantly increased the numbers of spontaneous locomotor activities, exhibited anxiogenic effect in the open field, elevated plus-maze and social interaction tests and decreased the immobility times of animals in tail suspension tests. The falling latencies in Rota-Rod tests did not change. This activity profile of MEO was similar to the typical psychostimulant caffeine. The exact mechanism of action underlying this stimulant-like effect should be clarified with further detailed studies.
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Authors
Ãzgür Devrim Can, Ãmide Demir Ãzkay, Hülya Tuba Kıyan, Betül Demirci,