Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5816815 | Phytomedicine | 2012 | 5 Pages |
Abstract
The methanolic extract of the fruits of Cornus officinalis S et Z. (Cornaceae) showed the significant neuroprotective activity against glutamate-induced toxicity in HT22 hippocampal cells. Chemical profile of n-BuOH fraction of the methanolic extract of C. officinalis fruits, which showed the most potent activity, was established using HPLC-diode array detector-electrospray-MS (HPLC-DAD-ESI-MS). Through bioactivity-guided isolation, five iridoid glycosides including one new compound, 7-O-butylmorroniside (1), loganin (2), morroniside (3), 7R-O-methylmorroniside (4), 7S-O-methylmorroniside (5) were isolated from the n-BuOH fraction. The protective activities of the isolated compounds, themselves, were not statistically significant. However, the hydrolyzed products of compounds 1, 4 and 5 significantly protected glutamate-injured HT22 cells up to 78 ± 2.2%, 60 ± 3.2% and 59 ± 2.5% of non-treated control, respectively.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Clinical Biochemistry
Authors
Eun Ju Jeong, Tae Bum Kim, Heejung Yang, So Young Kang, Sun Yeou Kim, Sang Hyun Sung, Young Choong Kim,