Glycyrrhizic acid and 18Î²-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation

Article ID	Journal	Published Year	Pages	File Type
5816865	Phytomedicine	2013	8 Pages	PDF

Keywords

CREB RPL13A RU486 PIP2 dual specificity protein phosphatase 1 PIP3 DUSP1 AP1 Mifepristone GSK3β eNOS GRE HO-1 SRB NSAID NF-κB PI3K NFAT DEX CRE 18β-glycyrrhetinic acid MAPK ROS Akt glycyrrhizic acid cAMP response element-binding COPD Chronic obstructive pulmonary disease Dexamethasone endothelial nitric oxide synthase sulforhodamine B nuclear factor of activated T-cells cAMP response element Non-steroidal anti-inflammatory drug nuclear factor kappa-light-chain-enhancer of activated B cells phosphatidylinositol (3,4,5)-trisphosphate phosphatidylinositol 4,5-bisphosphate phosphoinositide 3-kinase Glucocorticoid resistance Nitric oxide heme oxygenase 1 activator protein 1 protein kinase B mitogen-activated protein kinase Glycogen synthase kinase 3β Reactive oxygen species glucocorticoid receptor

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Glycyrrhizic acid and 18Î²-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation

Authors

Tzu-Chien Kao, Chi-Hao Wu, Gow-Chin Yen,