Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5816991 | Phytomedicine | 2011 | 10 Pages |
Abstract
In conclusion, we demonstrated that icariin has an in vitro inhibitory effects on osteoclasts differentiation that can prevent inflammatory bone loss. Icariin inhibited LPS-induced osteoclastogenesis program by suppressing activation of the p38 and JNK pathway.
Keywords
p38ACPCOX-2BMP-2BM-MSCsRANKLBMDPGE2TRAPNF-κBHIF-1αα-MEMIκBαOPGM-CSFHEFnuclear factor of kappa light polypeptide gene enhancer in B-cellsCbfa1/Runx2LPSIL-6FBSJnkc-Jun N-terminal kinasesDMSOERK1/2extracellular signal-regulated kinase1/2MAPKsp38 MAPKα-minimum essential mediumMTT assayOsteoprotegerinOsteoclastinterleukin-6IcariinGene expressionBone mineral densityELISAEnzyme-linked immunosorbent assaytumor necrosis factor-αDimethyl sulfoxidefetal bovine serumBone marrow-derived mesenchymal stem cellshypoxia inducible factor-1αTNF-αlipopolysaccharideICR miceNitric oxidepolymerase chain reactionPCRBone morphogenetic protein-2Prostaglandin E2mitogen-activated protein kinasesreceptor activator of NF-κB ligand
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Clinical Biochemistry
Authors
Tsai-Pei Hsieh, Shiow-Yunn Sheu, Jui-Sheng Sun, Ming-Hong Chen,