| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5817036 | Phytomedicine | 2011 | 8 Pages |
Abstract
The most effective dose of GEN, independent of Ca/D3 supplementation, was 54Â mg/day. Higher doses yielded no further improvement in bone biomarkers, histology or strength. Only 1000Â mg/day HED of genistein produced statistically significant changes in uterine weight of the SHAM-OVX. This study suggests that 54Â mg/day of GEN is the threshold dose for efficacy. In addition, supplemental calcium and vitamin D3, beyond normal dietary intake do not enhance the effects of genistein on improving measures of bone loss. This observation has implications regarding the use of calcium and vitamin D3 supplementation.
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Authors
A. Bitto, H. Marini, B.P. Burnett, F. Polito, R.M. Levy, N. Irrera, L. Minutoli, E.B. Adamo, F. Squadrito, D. Altavilla,